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filingDate 2012-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4d4a66a461cf0c2c58458fa88713c86
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publicationDate 2019-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10370402-B2
titleOfInvention Process for the preparation of fluticasone propionate form 1
abstract The invention relates to a novel crystallization process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronization. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water 10 and acetone, thereby causing fluticasone propionate to crystallize out of the solution as crystalline form.
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