| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a0ae5d9eaf673b4ff36da9e01b204b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3187a8870f9a626ce8b8702086538cf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05404493563a2e35e3847c32731d9d56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66467fe5b0acf469afb972f300bcfb87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d0446a5bd77c7da68216fc2e3f05d48 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70 |
| filingDate |
2016-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_520c80fac3c0dbd468bc685114172745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51ac4d4537b1235123b6ce897c87716c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad600f1b220055c84bcc72493231d5a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4869dad1a443464f4dce06d57d772d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f89bc3dc4dadc7d69c982cc1f682bceb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e022a029a9af74e86d8d51996d8251b |
| publicationDate |
2019-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10351911-B2 |
| titleOfInvention |
Methods and kits for determining predisposition to develop kidney diseases |
| abstract |
Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease. |
| priorityDate |
2010-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |