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filingDate 2017-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10349638-B2
titleOfInvention Human ARCAP transgenic mouse
abstract A non-human transgenic animal that contains in its genome a nucleic acid encoding human ARCAP operably linked to a liver-specific promoter. The transgenic animal expresses the human ARCAP protein and develops tumors of the liver, spleen, abdomen, or lymph. Also provided is a cell line derived from the non-human transgenic animal expressing the human ARCAP gene. Further provided is a method for producing a transgenic mouse by micro-injecting into a fertilized mouse oocyte a vector that contains a human ARCAP cDNA operably linked to a liver-specific promoter and transferring the micro-injected mouse oocyte into a foster mouse.
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