http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10343163-B2

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filingDate 2017-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10343163-B2
titleOfInvention System and method for a biomimetic fluid processing
abstract A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
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