Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_916075766043ce900399a4c2eee9f054 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4709 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D421-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D293-12 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D293-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D421-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M36-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 |
filingDate |
2016-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2019-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5626a5ff73c9ee960799e4d87aa513b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec775e4dda59cdc1025393aaf14398c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9143224533b93ef9b67bf49ffd37cc80 |
publicationDate |
2019-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-10335504-B2 |
titleOfInvention |
Heterocyclic molecules for biomedical imaging and therapeutic applications |
abstract |
Probes which target diffuse and fibrillar forms of amyloid beta (Aβ) are described. These probes demonstrate high initial brain penetration and facile clearance from non-targeted regions. The agents can be used to image amyloid quantitatively for monitoring efficacy of Aβ-modifying therapeutics and assist in premortem diagnosis of Alzheimer's disease (AD). Disclosed probes can bind Aβ aggregates of preformed Aβ1-42 fibrils in vitro and can be used to image fibrillar and diffuse plaques ex vivo in brain sections. Disclosed probes can be used to determine Aβ burden in early stages of AD. These probes can be used for multimodality imaging of Aβ. F-AI-187 (1 μM) can detect Aβ plaques in brain sections of APP/PS1 mice. F-AI-187 (10 μM) can detect Aβ plaques in the frontal lobe in a brain section of a patient with confirmed AD. Some probes can be used for fluorescence imaging of plaque. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11492590-B2 |
priorityDate |
2013-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |