| abstract |
The present invention provides a method for preventing or treating an allergic disease, comprising administering to a subject a composition comprising an extract from Illicium verum as an active ingredient. The extract from Illicium verum of the present invention reduces the secretion amount of increased histamine by compound 48/80 and the production amount of the increased allergenic cytokines (TNF-α, IL-4 and IL-8) by PMA and A23187. The Illicium verum extract of the present invention reduces edema, dermatitis and IgE concentration of serum in atopic dermatitis mouse model. The Illicium verum extract of the present invention may be efficiently use for prevention, improvement or treatment of various allergic disease such as edema, hypersensitivity, contact dermatitis, atopic dermatitis, skin allergy, asthma or urticaria as pharmaceutical compositions, skin external applications, cosmetic compositions or food compositions. |