http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323010-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b74452a889073845b47a40e23c273814 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-20 |
| filingDate | 2016-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3529cae496efef1715498b64854ec600 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a59930927fa05bb2cddc0522300e586 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d46631834301135848a6a8cce3044b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34bd4e6b73375d61f06f28db0d1fa4ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e2b74bccd9bae8b49c14109c898141f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25f6026802bcc24f8e3d4c16582cdfc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b954a6ce82acb6b407d20a869b8a8fc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9fa014ce2cbfba51fa1c25f31b68361 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c8d026ccc40c3957dd7322c97de9fdb |
| publicationDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10323010-B2 |
| titleOfInvention | Methods of chemical synthesis of substituted 10H-phenothiazine-3,7-diamine compounds |
| abstract | The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease. |
| priorityDate | 2015-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 507.