| abstract |
The present invention relates to therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. In one particular embodiment, the pharmaceutical composition can have the structural moiety of formula (I) or a pharmaceutically-acceptable salt of said compound: n nwherein group A is selected from the formulaen n nGroup B is aryl, R 1 is an optionally substituted aryl ring, an optionally substituted benzyl ring, CH 3 , or C 2 to 6 alkyl, and R 2 is hydrogen, an alkyl group, a halogen, or —(CH 2 ) n N(CH 3 ) 2 where n is an integer from 1 to 3. |