| abstract |
The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii ( T. gondii ) calcium dependent protein kinases (TgCDPKs) or Cryptosporidium parvum ( C. parvum ) and Cryptosporidium hominus ( C. hominus ) calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-α]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R 1 , and R 3 are defined herein. |