| abstract |
A compound has inhibitory activity on Discoidin Domain Receptor 1. A urea derivative is represented by the formula (I) or a pharmaceutically acceptable salt thereof: n nwherein, R 1 is trifluoromethyl, trifluoromethoxy, or pentafluorosulfanyl; each R 2 is independently a hydrogen atom or methyl which is optionally substituted by one hydroxyl or one saturated heterocyclyl having four to six ring-forming atoms; R 3 is a hydrogen atom, halogen atom, C 1 -C 3 alkyl, saturated heterocyclyl having four to six ring-forming atoms and optionally having an oxo group, or R 5 O—; and R 4 is phenyl, pyridyl, pyridazinyl, or pyrimidinyl, which phenyl, pyridyl, pyridazinyl, or pyrimidinyl is optionally substituted by one R 6 . |