abstract |
A cyclic peptide ( 10 ) includes two domains (D 1 ,D 2 ), each including three charged sub-domains ( 14, 16 ). The first domain (D 1 ) includes two anionic sub-domains ( 14 ) followed by a cationic sub-domain ( 16 ). The second domain (D 2 ) includes two cationic sub-domains ( 16 ) followed by an anionic sub-domain ( 14 ). The two domains are connected to one another and separated by a tri-glycyl linker ( 12 ). The cyclic peptide ( 10 ) is able to self-assemble into a network able to mimic an extracelluar matrix, and which promotes cell growth while resisting biofilm formation. |