http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10239875-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbd1d44888f5b41142d83de455096387 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4af70bcb7c2bc0ff0a920c3b40f564eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dcbdf3cf6d45ab8deaf41c25393f1a6 |
| publicationDate | 2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10239875-B2 |
| titleOfInvention | Naphthyridinyl hydrazine derivatives as potent peripheral analgesic agents |
| abstract | The naphthyridinyl hydrazine derivatives as potent peripheral analgesic agents are (E)-2-(substituted benzylidene)-1-(2,7-dialkyl-1,8-naphthyridinyl) hydrazines that provide effective peripheral analgesic activity, as demonstrated using the mouse writhing test. The new target compounds include at least one compound that demonstrates higher potency in providing analgesic relief in mice (Protection (%)=81.44) compared to the reference drug acetyl salicylic acid (Protection (%)=78.47). These results demonstrated that the target compound exerts acute analgesic action, suggesting that it may represent an alternative in the development of new therapeutic strategies. Preferably, the (E)-2-(substituted benzylidene)-1-(2,7-dialkyl naphthyridinyl) hydrazine has the formula: n nwherein R 1 and R 2 are alkyl, R 3 is hydrogen, and R 4 is NO 2 . |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2786673-C1 |
| priorityDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.