| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ca637dc687a011603834c661a175428 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D9-0054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D9-0063 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-02 |
| filingDate |
2016-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3827fef0eef32ec26bbaccc11c55bdab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8795718a469fa8f752a12b9a4dcc86ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29399b1e5a05caaf69b02dc0661de906
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7888a5b8336c0e8cd3dacd4e985156ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26787810b64e40120fdbfbcc9219e96f |
| publicationDate |
2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10221145-B2 |
| titleOfInvention |
Method for preparing anti-heart-failure medicine LCZ696 |
| abstract |
The present invention discloses a method for preparing an anti-heart-failure medicine LCZ696. The preparing method comprises the following step (formula (I)): in an organic solvent, a Sacubitril dicyclohexylamine salt reacts with valsartan under the effect of a sodium hydroxide aqueous solution, and the anti-heart-failure medicine LCZ696 is obtained. The preparing method of the present invention is simple in process and omits the procedures of ion exchange from a sodium salt to a calcium salt and hydrochloric acid dissociation in an existing production process, residues of calcium ions are avoided, and the production efficiency is effectively improved. |
| priorityDate |
2015-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |