http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10191048-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_64cf2a75f5ecc71194ac4bb27263bd9a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-104 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564 |
| filingDate | 2015-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0833675e1e9875769a82a3ce7093e1f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9d4ffe2085b1354fc8ab212056446c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d14b0f34cbb4bcfd418266d6848ac6df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af68b4a5b0089b5ca7cef94642171b02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b6ec7db17d237b0a9cb81ff79b6f284 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_844c31c98e90956224c3b1bee20b5701 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4272299502efc2c3b8545d7a2ba959e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89772f5e855e34a03cafbdbc685942c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b4eec3a233647778c1afc2ab6f7bb38 |
| publicationDate | 2019-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10191048-B2 |
| titleOfInvention | Fluorometric immunoassay for detection of anti-dsDNA antibodies |
| abstract | The present invention relates to the field of immunological methods, more precisely to the field of detection methods for antibodies against double-stranded DNA (dsDNA) for diagnostics of chronic autoimmune diseases, such as systemic lupus erythematosus (SLE). The fluorometric immunoassay method for detection of anti-dsDNA solves the technical problem of designing a method for detection of the aforesaid antibodies, which would be faster, cheaper and less toxic as the standard Farr-RIA method, but would have the same diagnostic specificity (which is 100%) and improved diagnostic sensitivity (for 3%). Detection of anti-dsDNA is based on detection of fluorescence in two fractions of samples, in the supernatant and in the sample with a precipitate, which contains immune complexes composed of added dsDNA and anti-dsDNA present in the patient's serum, wherein the detected fluorescence is a consequence of binding fluorescent dyes with dsDNA bound in the complexes or with free dsDNA. The method according to the invention allows obtaining reliable results, fast sample analysis and results availability to the attending physician, use of human and environmentally safe chemicals and lowering of costs in comparison to the standard Farr-RIA method. |
| priorityDate | 2014-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.