| abstract |
Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens ( Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis , human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum , and Vaccinia virus ) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter. |