http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10155753-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d0fc2b70675ee19bd5fc464f5ae9061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ec38905d57b9fda6d35ea26e720f958 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-10 |
| filingDate | 2016-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94abcaac446156fcabb4c8c8f5b42d7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e27dbe390be13621751e0a9aabbf62ee |
| publicationDate | 2018-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10155753-B2 |
| titleOfInvention | 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives, methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives |
| abstract | wherein X is selected from the group consisting of hydrogen, halogen, a cyano group, a trifluoromethyl (CF3) group, an amidine (C(═NH)NH2) group, and a 5-methyl-1,2,4-oxadiazole group, Y is selected from the group consisting of hydrogen, halogen, a phenyl group substituted with one or two substituents selected from the group consisting of halogen, methoxy, nitro, trifluoromethyl, and aminomethyl, CO—R′, COOR′, OH, O—R′, and NH—R′, each R′ is independently selected from the group consisting of C1-C18 alkyl, alkenyl, alkynyl, and —Z-alkyl (wherein Z is a heteroatom selected from the group consisting of O, S, and N or is —(CH2)m—), and m is an integer from 0 to 5. Also disclosed are methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives. The phenol derivatives and the pharmaceutical compositions can effectively inhibit the proliferation and migration of kinase-overexpressed cells and can be used for the prevention or treatment of various solid cancers and metastatic cancers. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11439623-B2 |
| priorityDate | 2015-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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