| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fda383378cdfb585182f89a0fd68b5ba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2017-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b889e012832219b9727d369f3e03ad9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afa42438becf43ddf1e10051ac1f8fe3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35690956c4bedbb88dd2b0498b6baaf4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b08e1f4e85574c01c6c69e96cf4893c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71de7bc59c65841d8f3e45bc8fdd4340 |
| publicationDate |
2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10139414-B2 |
| titleOfInvention |
Tn-MUC4 binding polypeptides and uses thereof |
| abstract |
The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11067578-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023014863-A1 |
| priorityDate |
2009-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |