Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f83734a45862157be1cc57b927717f5b |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-14143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14152 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14151 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-14144 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-14043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-14044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-14152 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-864 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
filingDate |
2018-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5338588d919a6e318355675bea6c2327 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4add749d8f942e04385d8e5928b5c729 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66bedd8b0ddafb5926d932dfa8f8b757 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfb8f6ab183bca3b767d622797b36621 |
publicationDate |
2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-10138496-B2 |
titleOfInvention |
Vectors with modified initiation codon for the translation of AAV-Rep78 useful for production of AAV |
abstract |
The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation of the parvoviral Rep78 protein is a suboptimal initiation codon that effects partial exon skipping upon expression in insect cells. The insect cell further comprises a second nucleotide sequence comprising at least one parvoviral (AA V) inverted terminal repeat (ITR) nucleotide sequence and a third nucleotide sequence comprising a sequences coding for the parvoviral capsid proteins. |
priorityDate |
2006-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |