| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2950e4de7d6312df9264e28c552b0fe3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-14 |
| filingDate |
2014-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c9672f1a6828b85fde2a18e1dd06724
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f182594a7d9f801f621732b26f4c5e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad694b54628c6b7a9ef9777a703131fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_098b2fc9cbd12eb0e8d8e75662c9f37d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_032816cf6c31ac6e0e9772e9d25f6506
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ad23733750839a9936461af8dd35f81 |
| publicationDate |
2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10131689-B2 |
| titleOfInvention |
Separation and purification method for vancomycin hydrochloride of high purity |
| abstract |
Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange chromatography and obtaining a concentrate by nanofiltration desalination and concentration; (2) adjusting the concentrate with a hydrochloric acid solution and then performing a column chromatography using a reverse chromatography column for the adjusted concentrate; (3) collecting the chromatographic solution of vancomycin to obtain a mixed chromatographic solution; (4) adjusting the mixed chromatographic solution, and separating the solution and the salts by nanofiltration desalination and concentration to obtain a concentrate; and (5) obtaining a vancomycin dry powder with a chromatographic purity of up to 99% and a pure white appearance by dehydrating and drying the concentrate of step (4), or by solvent crystallization or salting-out crystallization. |
| priorityDate |
2013-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |