| abstract |
A method of treating or preventing multiple sclerosis includes administering a therapeutically effective amount of a cyclohexane derivative represented by Formula (I): n nwherein A is a substituent represented by Formula (IIa) or (IIb):n n nR 1 and R 2 are each independently a hydrogen atom, chlorine atom, C 1 -C 3 haloalkyl, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or cyano; R 3 is a hydrogen atom or chlorine atom; R 4 is a fluorine atom, hydroxymethyl, or hydroxyl; R 5 and R 6 are each independently a hydrogen atom, fluorine atom, C 1 -C 3 haloalkyl, carboxyl, methoxycarbonyl, ethoxycarbonyl, C 1 -C 4 alkoxy, hydroxyl, or C 2 -C 5 alkylcarbonyloxy, or optionally together form oxo; R 7 and R 8 are each independently a hydrogen atom or fluorine atom; Y is an oxygen atom or sulfur atom; and Z is a nitrogen atom or methine or a pharmaceutically acceptable salt thereof to a mammal. |