| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a1f523afe2ba08f0c31259dc2b53949 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-413 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-0279
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K6-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K6-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K6-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K6-0085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q11-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K6-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K6-838
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-42 |
| filingDate |
2014-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7aac2c11c433f466bed3ea9b1c51c017
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc099930335b11713023c12eb8fa4689 |
| publicationDate |
2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10130566-B2 |
| titleOfInvention |
Hollow calcium phosphate particles |
| abstract |
The object is the invention is to provide hollow, and preferably porous, spherical CaP particles preferably without the use of strontium ions. This is achieved by a method comprising the steps: a) Providing an aqueous buffer solution of purified water having a pH of 6-10 comprising 20-200 mM sodium ions, 0.1-10 mM potassium ions and 1-10 mM phosphate ions, and wherein the buffer solution is essentially free from strontium; b) adding calcium ions in the range of from 0.1 to less than 2 mM, and magnesium ions in the range of 0.01-5 mM to the buffer solution and forming a mixture; c) heating the mixture of step b) at 60-200° C. for at least 5 minutes d) isolating the formed particles; and e) optionally washing the isolated particles using a suitable solvent. The particles comprise 40-70 weight % of calcium, 20-40 weight % of phosphate and 1-25 weight % magnesium. The Ca/P weight ratio is in the range of 1.10 to 1.90 and more than 80 % of the particles have a particle size between 200 to 1500 nm. The particles are essentially free from strontium. A composition comprising the particles may be used for remineralization of teeth or as bone void filling material. |
| priorityDate |
2013-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |