| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e87c125af2844d035abe766ad6a22f98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C275-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06078 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-16 |
| filingDate |
2015-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f62035f871b84817be9b10c05698d55a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a2500601141f9b76a46054061e8ebb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_824cad2e3bdca2ff4077066139fe8e6b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e542eae56122ec7e84467d33602ccf2 |
| publicationDate |
2018-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10112974-B2 |
| titleOfInvention |
Method for the production of 18F-labeled active esters and their application exemplified by the preparation of a PSMA-specific PET-tracer |
| abstract |
Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18 F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18 F − are described. The active ester including [ 18 F]F-Py-TFP and [ 18 F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [ 18 F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542234-B2 |
| priorityDate |
2014-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |