| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcb146c68b67089013b4c7a614504254 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-914
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-825 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B11-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-581
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y308-01005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 |
| filingDate |
2016-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_604c15333bbb73434a68da252c7ac20a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1b23e5b280aa86bf4673a28a7c77141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0af1fac63f7207dc7d23a2b1bd6952b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abdbdbc856bfd7e2894a4fe3d5acbc03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_463c34ea78befc4deb790cec3eec5472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04aff28afd316dbb438d9549f77a131a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e297326cd14dcb511f6f5b4ea3b39c75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81ab81405d3f0856a0cb250e3be42389 |
| publicationDate |
2018-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10101332-B2 |
| titleOfInvention |
Covalent tethering of functional groups to proteins and substrates therefor |
| abstract |
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4206674-A1 |
| priorityDate |
2004-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |