| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91215 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M36-14 |
| filingDate |
2015-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d35d039fac10ca56cab5e0bf1d0eab52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a600c0f84cc5aa8b7e8f3f206944372
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_572dd1352775a180c23bcbc3da4a6a9b |
| publicationDate |
2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10039844-B2 |
| titleOfInvention |
Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2 |
| abstract |
A novel pyruvate kinase M2 (PKM2)-specific activator, [11C]DASA-23 and derivatives thereof, and methods for their rapid synthesis are provided. The probes are particularly useful in methods for the non-invasive positron emission tomography (PET) detection and imaging of PKM2 expression in subcutaneous and orthotopic tumors. [11C]DASA-23 cell uptake correlates with PKM2 protein expression in cultured tumor cells and orthotopic tumors are delineated from the surrounding normal brain tissue in vivo. |
| priorityDate |
2014-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |