| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5ad8562c578b061df7a2c3aee9d0e24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 |
| filingDate |
2017-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ef3a0c7a93334fac38218cca312ca55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1196b7cd1e5c9b20d76394195547353b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad6f35a752b820392913ee2fbe2a2f95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7a7660a0353810ff1ffc81aef74524f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2795521fdff159d9356ad984d385f99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7346bec748341c47dd8f0d682549dd12 |
| publicationDate |
2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10035795-B1 |
| titleOfInvention |
Phenothiazine derivatives having CaM inhibitory activity |
| abstract |
The present invention provides a phenothiazine derivative or a pharmaceutically acceptable salt thereof, a method of preparing a compound selected therefrom and a pharmaceutical composition containing the compound as an active ingredient. The phenothiazine derivative according to the present invention has an effect of inhibiting calmodulin (CaM; calcium-modulated protein) and thus helps cell death by maintaining the intracellular level of calcium in lung cancer cells at high concentration. Accordingly, the phenothiazine derivative according to the present invention can be usefully used to prevent or treat malignant tumors such as lung cancer. |
| priorityDate |
2017-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |