| abstract |
The present invention relates to compounds of formula I n nwhereinn R 1 is hydrogen, F or Cl; L is a bond or lower alkylene; R 2 is —(CH 2 ) n O-lower alkyl, lower alkyl substituted by halogen, —(CH 2 ) n C(O)O-lower alkyl, phenyl substituted by lower alkyl or halogen, or is a 5 or 6-membered heteroaryl group, selected from pyridinyl, pyrimidinyl, pyridazinyl, thiazolyl, imidazolyl, pyrazolyl or triazolyl, which are optionally substituted by lower alkyl, halogen, lower alkoxy, ═O, benzyloxy, cycloalkyloxy, hydroxy, cyano, lower alkyl substituted by halogen, or by —(CH 2 ) n O-lower alkyl;n n is 1, 2 or 3; n R 3 is hydrogen, lower alkyl or —(CH 2 ) n O-lower alkyl; R 4 is phenyl, pyridinyl or pyrimidinyl, optionally substituted by F; Y is CF or CCl;n nor to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomers thereof.n nn The compounds may be used for the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression and diabetes type 2. |