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publicationDate 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10011560-B2
titleOfInvention Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents
abstract Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.
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