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filingDate 2012-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10010274-B2
titleOfInvention Systems, devices and methods for in situ calibration of implantable sensors
abstract The systems, methods, and devices described herein generally involve monitoring and/or quantification of various analyte levels in a biological fluid using one or more implantable sensors. In various aspects, systems, methods, and devices described herein can provide for the in situ calibration and/or cleaning of such sensors when implanted in the patient. The systems and devices disclosed herein can, for example, continuously or serially measure analytes within a biological fluid in vivo (e.g., without extracting the biological fluid from the patient) and periodically calibrate and/or clean the sensor without using finger sticks or additional, invasive calibration techniques. By way of non-limiting example, systems and devices disclosed herein can enable continuous monitoring of analyte concentrations (e.g., glucose) in subcutaneous interstitial fluid for several hours to a few days.
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