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filingDate 2015-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10001490-B2
titleOfInvention Biochemical markers for pulmonary and other diseases
abstract Provided is a method of bioassay for the quantification of peptide fragments elevated in lung diseases such as COPD, SCC, or IPF. The peptide fragments comprise a neo-epitope formed at a cleavage site by cleavage in vivo of elastin by a proteinase. In the method a sample is contacted with an antibody having specific binding affinity for the neo-epitope amino acid sequence and determining the level of binding is determined where the antibody binds one of the following terminal sequences: . . . FGPGVV, . . . VPGLGV or IKAPKL . . . . Also provided are antibodies and immunoassay kits for use in such methods.
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