| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4021f8d8a53258a5a3615b4139dd1eee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5891d4e35d150b17393e88de6c85cb14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ddfb13a17b10438e8d5a9e2a0facb87 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 |
| filingDate |
2014-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cebe77903541ed59e237c19f729638b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9618536e0e4c50d9bf61f9b8e89a8c8 |
| publicationDate |
2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10000746-B2 |
| titleOfInvention |
LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof |
| abstract |
Disclosed herein are compositions for inactivating the human TCR-alpha gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHEs. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefore are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11591582-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021214714-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10927367-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020109385-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793843-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023141602-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11732255-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023081756-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021147818-A1 |
| priorityDate |
2013-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |