http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10000541-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f7c41518ab2564e700927ab7bf2ff79 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525 |
| filingDate | 2017-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cef7453dc9feac6f7aa7fdce247fbead http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d3cf46e62e8d768a762883a2518444d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db23e2eff320885d8ecf33b69aa6d238 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_596e91817edba2c66f6f07323a268f33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd9e53ef573b5f6bac35e6dc21347ff1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14972d2c599a3b7d1ee82d4d8ee8c9b3 |
| publicationDate | 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10000541-B2 |
| titleOfInvention | Trail cell-penetrating peptide-like mutant MUR6 and preparation method thereof |
| abstract | A TRAIL cell-penetrating peptide (CPPs)-like mutant MuR6 and a preparation method and the application thereof. The amino acid sequence of the mutant is SEQ ID NO: 2. The mutant selectively transforms the amino acid coding sequence of No. 114-119 of the outer fragment of the TRAIL wild-type protein cell membrane from VRERGP to RRRRRR, i.e., mutates valine into arginine on the 114 th coding sequence, glutamic acid into arginine on the 116 th coding sequence, glycine into arginine on the 118 th coding sequence and proline into arginine on the 119 th coding sequence, turning the coding sequence of N-terminal of the mutant protein into that of six arginines and making it a protein containing CPPs-like structure. Having a superior therapeutic effect on different types of tumor, the TRAIL mutant is a new generation of high-efficient drug for inducing tumor apoptosis of much potential. |
| priorityDate | 2015-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 176.