| abstract |
This invention relates to compounds of structural Formula I: where n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 represents alkenyl, alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, -NHC (= Y) R4, -NHC (= Y) NR5Rx, -NHC (= O) OR4, -NHSO2R4, C (= Y) NR4R5 , C (= O) OR6 [de Y represents oxygen or sulfur], OR5, -O (C = O) NR4R5, O-acyl, S (O) mR4, -SO2N (R4) 2, cyano, amidino or guanidino [where R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclyl alkyl or cycloalkylalkyl and m is an integer from 0 to 2; R5 is hydrogen or R4; Rx is R4 or —SO2N (R4) 2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluoro, alkyl, cycloalkylalkyl or aralkyl; A represents OH, OR4, -OC (= O) NR4R5, O-acyl, NH2, NR4R5, -NHC (= Y) R4, -NHC (= Y) NR5Rx, -NHC (= O) OR4, -NHSO2R4, as well as methods for their synthesis. This invention also relates to pharmacological compositions that contain the compounds of this invention and methods for treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pneumonia, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis , atherosclerosis, neointimal proliferation, which leads to restenosis and coronary heart failure, stroke, kidney disease, tumor metastases, as well as other inflammations eating disorders, which are characterized by excessive expression and excessive activation of matrix metalloproteinase, using compounds. |