http://rdf.ncbi.nlm.nih.gov/pubchem/patent/UA-98102-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9a36328274867f46f8fc1fb9c868703 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-32 |
| filingDate | 2006-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc2f0e9e1a21c360a56c90d4535f97bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f035e544296376009163d2180240ad0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cf3c3aec642f21a6f14716d79005786 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cd445d4f5dc40362f0aeeb61c6a4c37 |
| publicationDate | 2012-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | UA-98102-C2 |
| titleOfInvention | METHOD FOR PRODUCING HIGH-PURITY POLYMORPH (I) DONEPEZIL HYDROCHLORIDE |
| abstract | The present invention provides a novel, commercially available, and economically advantageous method of producing high-purity 1-benzyl-4 - [(5,6-dimethoxy-1-indanone) -2-yl] methylpiperidine hydrochloride, i.e. donepezil hydrochloride, shown in the following reaction In one of the key steps of the method, the hydrochloride of 5,6-dimethoxy-2- (pyridin-4-ylmethylene) indan-1-one was saturated during hydrogenation using Pd on coal. received 4 - [(5,6-dimethoxy-1-indanone) -2-yl] methylpiperidine with more than 97% At the crystallization stage of donepezil, the hydrochloride was crystallized from an aqueous alcohol solvent to give Polymorph (I) with at least 99.95% purity determined by HPLC. |
| priorityDate | 2005-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.