http://rdf.ncbi.nlm.nih.gov/pubchem/patent/UA-96107-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1af441fa2176a58e117194bdb823b427 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2010-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bba6c0f3e37927244613d1e1b527aef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d643c3a42d0bc9bf7806987f0028fd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_038a2ed06919752145d715baeea7c7e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4bb44937122375400f663a1c5a34c33 |
| publicationDate | 2011-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | UA-96107-C2 |
| titleOfInvention | Substituted (6-acetyl-8-cyano-5-methyl-3-oxo-7-aryl-2,3-dihydro-7H-thiazole [3,2-a] pyridine-2-yl) ACETIC ACIDS AND METHOD [Substituted (6-acetyl-8-cyano-5-methyl-3-oxo-7-aryl-2,3-dihydro-7H-thiazolo [3,2-a] pyridin-2-yl) acetic acids and acids RECEIPTS |
| abstract | Substituted (6-acetyl-8-cyano-5-methyl-3-oxo-7-aryl-2,3-dihydro-7H-thiazolo [3,2-a] pyridin-2-yl) acetic acid of general formula I is offered , There is Ar = CH, 4-NO-CH, 4-Cl-CH, 4-CH-CH, 4-CHO-CH, and the method of their preparation, which consists in condensing equal amounts of acetylacetone with cyanothioacetamide and aromatic aldehyde formulas of ArCNO in an organic solvent - ethanol, in the presence of a catalyst - morpholine, at room temperature for 2.5-3 hours. The product is isolated from the reaction mass with 10% hydrochloric acid. The resulting pyridinedione is boiled with maleic anhydride in glacial acetic acid for 4-5 hours prior to the formation of the target product. The claimed solution provides a wider range of thiazolopyridinylacetic acids, allows to reduce the duration of the process to 6.5 hours, of these compounds in medicine, biology and pharmacy. [Substituted (6-acetyl-8-cyano-5-methyl-3-oxo-7-aryl-2,3-dihydro-7H-thiazolo [3,2-a] pyridine] -2-yl) acetic acids of general formula I, where Ar = CH, 4-NOH, 4-cl-cH, 4-CHH, 4-CHO-CH, and the method for their preparation, which is to condense equal molar amounts of acetylacetone with cyanothioacetamide and aromatic aldehyde of the formula ArCHO in an organic solvent - ethanol, in the presence of a catalyst - morpholine, at room temperature for 2.5-3 hours. The product is recovered from the reaction mass with 10% hydrochloric acid. The resulting pyridinedione is boiled with maleic anhydride in glacial acetic acid for 4-5 hours prior to the formation of the desired product. |
| priorityDate | 2010-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.