| abstract |
The invention relates to a compound of formula (I), in which A, A, A and A denote CRa or N; R1 and R 'are such that one represents H, halogen, C-C-alkyl, C-C-alkoxy, alkyl-OH, CF, cyano, carboxyl and carboxamido; and the other means H; halogen; CF; OH; SH; nitro group; amino group; NH-OH; NH-CO-H; NH-CO-OH; NH-CO-O (alkyl); NH-CO-NH; carboxyl; CN; CO-NH; X- (CH) m-alkyl; X- (CH) m-cycloalkyl; X- (CH) m-heterocycloalkyl; X- (CH) m-aryl or X- (CH) m-heteroaryl, where X = simple bond, CH, CH = CH, CH-O, CH-NH, CH-C (O), CH-C (O) -O, CH-C (O) -NH, CH-NH- (CO), CH-NH-S (O), CH-NH-S (O), O, S, NH, O-C ), C (O) -NH, -NH-C (O), -NH-C (O) -C (O) -, -NH-C (O) -NH; NH-CS, NH-S (O) or NH-S (O); m = 0, 1 or 2; or R1 and R 'together with C to which they are attached, form either the radical = O; = S; = N-OH; = N-NH; -N-NH-CO-NH; = CH-OH; = Y- (CH) m-aryl or = Y- (CH) m-heteroaryl, where Y means CH, CH-CO, CH-CO-NH, N, N-O or N-NH-, where m = 0, 1 or 2, or cycle; R and R'denote H, halogen, CF, nitro group, cyano group, alkyl, hydroxyl, mercapto group, amino group, alkylamino group, dialkylamino group, alkoxyl, alkylthio group, free or esterified carboxyl, carboxamido group, alkyl (C 1-4) alkyl- CO and NH ; p = 1-3 and p '= 1-4; Ra means H; halogen; CF; hydroxyl; mercapto group, nitro group; amino group; NH-OH; NH-CO-H; NH-CO-NH; carboxyl; CN; CO-NH; Y- (CH) n-alkyl; Y- (CH) n-cycloalkyl; Y- (CH) n-heterocycloalkyl; Y- (CH) n-apyl or Y- (CH) n-heteroaryl, where Y is O, S, NH, O-C (O), C (O) -NH, NH-C (O); NH-S (O) or NH-S (O), where n = 0, 1, 2 or 3; moreover, all alkyl radicals, alkoxy radicals, alkylthio groups, cycloalkyl, heterocycloalkyl, aryl and heteroaryl radicals are optionally substituted; and wherein the compound is in any tautomeric and isomeric form and in the form of salts as a medicament. R and R 'are such that one means H, halogen, C-C-alkyl, C-C-alkoxy, alkyl-OH, CF, cyanogenyl |