| abstract |
This invention relates to compounds of formula (I), their N-oxide forms, pharmaceutically acceptable additive salts and their stereochemically isomeric forms, where m means 1, n means 1, Z is N or C, in particular N; X is alkyl, in particular methyl; X is alkyl or alkyl-NR-, in particular propyl, -ethyl-NR- or -propyl-NR-; -Y- represents -NR-Alkyl-CO-NR-, -Het-Alkyl-CO-NR- or -Het-CO-NR-, where -Alkyl linker in -NR-Alkyl-CO-NR- or -Het -Alkyl-CO-NR- is optionally substituted by one or, if possible, two or more substituents selected from hydroxy, halogen and phenyl; R is hydrogen, chlorine, fluorine or bromine; R is -Alkyl-, in particular ethyl or methyl; R is hydrogen; R is hydrogen; R, R and R are hydrogen; He is selected from piperazinyl or piperidinyl, in particular is -piperazinyl; Not selected from pyrrolidinyl or piperidinyl, in particular pyrrolidinyl, where said pyrrolidinyl is optionally substituted by hydroxy. This invention relates to compounds of formula (I), their N-oxide forms, pharmaceutically acceptable addition salts and their stereochemically isomeric forms, where dem means 1, n means 1, Z represents N or C, in particular N; X represents Calkyl, in particular methyl; X represents Calkyl or Calkyl-NR-, in particular propyl, -ethyl-NR-or -propyl-NR-; -Y- represents -NR-Calkyl-CO-NR-, -Het-Calkyl-CO-NR- or -Het-CO-NR-, where -Calkyl linker in -NR-Calkyl-CO-NR- or -Het -Calkyl-CO-NR- optionally substituted by one or, if possible, two or more substituents selected from hydroxy, halogen and phenyl; Rrepresents hydrogen, chlorine, fluorine or bromine; Rrepresents -Calkyl-, in particular ethyl or methyl ;Rrepresents hydrogen;Rrepresents hydrogen;R, R, Rrepresents |