| abstract |
The invention relates to compounds of formula (I) in which X1, X2, X3, X4, Z1, Z2, Z3, Z4 and Z5 mean independently a hydrogen or halogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C1 -C6-fluoroalkyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, cyano, C (O) NR1R2, nitro, NR1R2, C1-C6-thioalkyl, -S (O) -C1-C6-alkyl, -S ( O) 2-C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5 or an aryl group; X5 is a hydrogen or halogen atom or a C1-C6 alkyl, C1-C6 fluoroalkyl group; R is a 4-, 5-, 6- or 7-indolyl group, optionally substituted, Y is a hydrogen atom or a C1-C6 alkyl group; n is 0, 1, 2 or 3; R1 and R2 are independently a hydrogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl or aryl group; or R1 and R2 form, together with the nitrogen atom to which they are bonded, an azetidine, pyrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine, homopiperazine group, said group being optionally substituted with a C1-C6 alkyl, C3-C7 cycloalkyl A -C7 cycloalkyl-C1-C3 alkyl or aryl group; R3 and R4 are independently a hydrogen atom or a C1-C6 alkyl or aryl group; R5 is a C1-C6 alkyl or aryl group; in the form of a base or an acid addition salt; and in the form of a hydrate or solvate. The method of preparation and use in therapy. |