abstract |
Organo-modified silica-based material used in the manufacture of a stationary phase for liquid chromatography contains a portion that is unmodified silica and part 5, which includes organic groups attached to the silica. A method of manufacturing a silica-based organically modified material, which comprises mixing in an aqueous medium a silica-based material and an organosilane compound, and reacting the mixture. The stationary phase separation material, which is made by functionalizing silica-based organomodified material, is also described. |