| abstract |
The present invention relates to 3-aminopyrrolidine derivatives of formula I: And (where R, R, R, R, R, R, R, R, X, Y and Z have the above meanings), which are useful as modulators of chemokine receptor activity. these compounds are useful as modulators of chemokine receptors and, more specifically, as modulators of CCR2 and / or CCR5 receptors. These compounds and compositions of the present invention may bind to chemokine receptors, such as chemokine receptors CCR2 and / or CCR5, and useful for the treatment of diseases, activity-related chemokines, such as CCR2 and / or CCR5, such as atherosclerosis, stenosis, lupus, rejection of transplanted organs and rheumatoid arthritis. ) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and, more specifically, as modulators of CCR2 and / or CCR5 receptors. These compounds and compositions of the present invention may bind to chemokine receptors, such as chemokine receptors R and / or CCR5, and are useful for the treatment of diseases associated with the activity of chemokines, such as CCR2 and / or CCR5, such as atherosclerosis, restenosis, tetanus, transplantation, and rheumatoid arthritis. |