| abstract |
This invention relates to a compound of the formula I: I or a pharmaceutically acceptable salt of such a compound, where: X is -C(R)= or -N=; R is C-C-alkyl, substituted C-C-alkyl, C-C-cycloalkyl, substituted C-C-cycloalkyl, phenyl, substituted phenyl, heterocycle or substituted heterocycle; R is hydrogen, n-C-C-alkyl, C-C-cycloalkyl-C-C-alkyl or a group of formula IIII, provided that when R is C-C-alkyl or substituted C-C-alkyl, R is hydrogen or methyl; R, R, and if X is -C(R)=, R is independently hydrogen, fluorine, or methyl, provided that no more than one of R, R, and R can be other than hydrogen; R is hydrogen or C-C-alkyl; R is hydrogen, C-C-alkyl or C-C-cycloalkylcarbonyl, provided that when R is other than hydrogen, R is hydrogen; R is hydrogen or C-C-alkyl; and n is an integer from 1 to 6 inclusive. The compounds of the present invention are useful for activating 5-HT receptors, inhibiting the transudation of neuronal proteins, and treating or preventing migraine in mammals. This invention relates to a compound of formula I: I or a pharmaceutically acceptable salt of such a compound, where: X is -C(R)= or -N=; It is C-C-alkyl, substituted C-C-alkyl, C-C-cycloalkyl, substituted C-C-cycloalkyl, phenyl, substituted phenyl, heterocycle or substituted heterocycle; It is hydrogen, n-C-C-alkyl, C-C-cycloalkyl-C-C-alkyl or a group of formula IIII, provided that when R is C-C-alkyl or substituted C-C-alkyl, it is hydrogen or methyl; R, Rы, if X is -C(R)=, R independently of each other is hydrogen, fluorine or methyl, provided that no more than one of the substituents R, R, and R can be different from hydrogen; It is hydrogen or C-C-alkyl; It is hydrogen, C-C-alkyl or C-C-cycloalkylcarbonyl, provided that when R is different from hydrogen, it is hydrogen; It is hydrogen or C-C-alkyl; and n it |