| abstract |
A compound represented by the following formula (I): , (I) , (II) , (III) [wherein X1 represents oxygen, etc.; X2 represents oxygen, etc.; R1 represents an alkylsulfonyl or another group on the ring A; R2 represents, e.g., C3-7 cyclic alkyl optionally substituted by halogeno, etc.; R3 represents a substituent on the ring B, e.g., lower alkyl; the formula (II) [Chemical formula 1] (II) represents 6- to 10-membered aryl, etc.; and the formula (III)[Chemical formula 1] (III) represents a mono- or bicyclic heteroaryl which optionally has a substituent represented by the R3 in the ring B and in which the carbon atom bonded to the nitrogen atom of the amide group in the formula (I) forms C=N in cooperation with the nitrogen atom of the ring] or apharmaceutically acceptable salt of the compound. The compound and salt function to activate glucokinase and are useful as a therapeutic agent for diabetes. |