http://rdf.ncbi.nlm.nih.gov/pubchem/patent/UA-81039-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 |
| filingDate | 2004-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9823889dd90f9c9a56c2e9403b99c16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c93253feb793680b8124284c539bfb2b |
| publicationDate | 2007-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | UA-81039-C2 |
| titleOfInvention | Method of preparation of n-(1-oxopentyl)- n-[[ 2-(1tetrazol-5-yl)[1,1 -biphenyl]-4-yl]methyl] -l-valine (valsartan) |
| abstract | From the starting 4-bromomethyl-2'-(l-triphenylmethyltetrazol-5-yl)biphenyl, N-((2'(1-triphenyl-methyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester of formula 7 is obtained via a reaction with L-valine benzyl ester, and is converted to valsartan of formula I via a reaction with valeryl chloride and removing of protective groups. The method consists in converting, with hydrochloric acid, N-[(2'-(l-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester of formula 7, obtained in the first stage, to N-[(2'-(l-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester hydrochloride of formula III, which is optionally re-crystallized. , (I) |
| priorityDate | 2003-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.