| abstract |
The invention relates to a method for producing cetirizine of formula I, as well as {2- [4- (EMBED Equation.3-phenyl-p-chlorobenzyl) piperazin-1-yl] ethoxy} acetamides of formula II, where R1 and R2 independently represent C1-4alkyl , which may be substituted by phenyl, C2-4alkenyl or cyclohexyl, or R1 and R2 together with an adjacent nitrogen atom form a morpholine group. According to the process, the acetamide of formula II is hydrolyzed, if necessary, in the presence of an interfacial catalyst to give cetirizine. |