| abstract |
The present invention relates to compounds of general formula (I), their N-oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric forms, wherein Alk is C1-6alkanediyl; n represents 1 or 2; X represents -O-, -S-, -S (= O) - or -S (= O) 2-; each R1 independently represents hydrogen, halogen, C1-4alkyloxy, nitro, hydroxy or C1-4alkyloxy; D represents indole, benzisoxazole, benzisothiazole, 2H-benzopyranone, phenoxyphenyl, benzamide, benzophenone or benzopyrimidinone having antagonistic activity against the Central -adrenoceptor. The invention also relates to their preparations, pharmaceutical applications and compositions. |