http://rdf.ncbi.nlm.nih.gov/pubchem/patent/UA-57689-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3497d30acc9f98da2574cd3a548aff83 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 |
| filingDate | 2003-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6cfdfddb8c53d86624ee26abdec9a9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_016957855516b48d139e97aa014baac9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dc025789d11e90e9016ce146458c95f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d34c7b86bf70b62ade60710252c0cff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad33f20fd396cefcc340865b2f11ee55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44a8d7d44f9317e4d2569cc341d5fc0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6eba641e5af65e71334badd1905f20f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f17a15c6b1dff63201b0599d2fd6c395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b81aaf530f2e89ec1e3190ae6d608e9 |
| publicationDate | 2006-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | UA-57689-C2 |
| titleOfInvention | Method for producing substance of insulin suitable for immediate release dosage form |
| abstract | The method for producing the substance of insulin suitable for immediate release dosage form comprises the aqueous and alcohol extraction of the porcine pancreas followed by concentration and isolation of insulin substance from the extract. Then the substance is purified chromatographically with theaim of discarding proinsulin, the foreign proteins, and the insulin-related impurities. The product is crystallized. The substance isolated is dissolved in the acid and mixed with the aqueous solutions of other ingredients. The porcine insulin substance is subjected to the reversed-phase chromatography on the silica gels C8 or C18. With the aim of purifying the substance from proinsulin and the foreign proteins, the elution is performed employing aqueous-organic solution with pH not exceeding 3.5 comprising 12-21% of isopropanol or propanol (preferably 18-20%) and no more than 0.25 M sodium acetate, ammonia acetate, ammonia sulfate, or sodium sulfate (preferably 0.01-0.06 M). The substance is purified from the insulin-related impurities employing isocratic mode of elution or the gradient of the organic modifier. The substance of insulin is suspended in the water. pH is adjusted to 3.1-3.2 with the acid. Then the aqueous solution of the buffering and isotonic agents with the preserving agents is prepared, and pH is adjusted to 7.6-7.8 with the alkali. Finally, the first solution is added to the second one. |
| priorityDate | 2003-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.