http://rdf.ncbi.nlm.nih.gov/pubchem/patent/UA-48014-A1
Outgoing Links
| Predicate | Object |
|---|---|
| filingDate | 1987-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3acf8e332c869ee33b11cc8dfd03fd6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31738f22ae3121825f06e76c1532ed14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b2b17880e08cb6b812d352bbae236b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f24abe04c469ead2eeb0a1625b6bc45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e838ea0357df07eef03861647432858 |
| publicationDate | 2002-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | UA-48014-A1 |
| titleOfInvention | <font face = "Symbol"> b </font> -PHENYLETHYLAMIDES 4- (R-BENZAMIDO) -BENZOLSULPHONYLOXAMINIC ACIDS WHICH EXPRESS ANTI-ALLERAGINISTIN |
| abstract | The invention relates to sulfonic acid derivatives, in particular 4- (R-benzamido) -benzenesulfonyloxamic acid B-phenylethylamides, wherein R is hydrogen, 4-methyl or 2-methoxy-group, which exhibit antiallergic and analgesic activity that can be used in medicine. The aim is to create new more active and less toxic substances of this class. The target compounds are synthesized in a reaction between 4-aminobenzenesulfonyloxamic acid NaOH,, -phenylethylamide and the corresponding benzoic acid chloride derivative. The yield in% t.ll ° ° and the gross formula, respectively, are: a) 84; 218-219; C23Η22N3O5S; b) 80; 234-235; C24H23N3O5S c) 81, 212-214; C24H23N3O6S. The degree of analgesic activity of the new compounds is 59-63 compared with 482% for analgin and antiallergic activity after 1 hour. after administration of 42-43 compared with 31% for diphenhydramine, while the toxicity is 4342-4622 compared with 267-1197 mg / kg for known compounds. |
| priorityDate | 1987-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.