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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-08
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16
filingDate 1993-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1999-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber UA-26400-C2
titleOfInvention METHOD OF OBTAINING DERIVATIVE ERGOLICH
abstract The invention relates to a process for the preparation of an ergoline derivative of formula (l): wherein R1 represents an ethyl group, R2 represents a dimethylaminopropyl group (CH3) 2N (CH2) 3, R3 represents allyl, R4 and R5 represent a hydrogen atom. This substance is obtained by reacting an ergoline amide of formula (ll) with 1-4 equivalents of isocyanate of formula (lll): The reaction is carried out in a solvent such as dichloromethane, 1,1-dichloroethane or toluene, at a temperature of from 35 ° C to 60 ° C, in the presence of CuCl or CuCl2 and a phosphorus compound selected from PPh3, P (n-CIPh) 3, P (n-MePh) 3 and MePh2P.
priorityDate 1992-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 31.