http://rdf.ncbi.nlm.nih.gov/pubchem/patent/UA-136202-U
Outgoing Links
| Predicate | Object |
|---|---|
| filingDate | 2019-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | UA-136202-U |
| titleOfInvention | METHOD OF SIMULATION OF SYSTEMIC AUTOIMMUNE VASCULITIS |
| abstract | The method of modeling systemic autoimmune vasculitis is the introduction of complete Freund's adjuvant with a solution of spleen deoxyribonucleic acid in cattle. White rats with an average weight of about 200-250 g under ether inhalation anesthesia at 2 points of the root of the tail is introduced a complete Freund's adjuvant with a solution of spleen deoxyribonucleic acid in cattle (1 mg per 100 g) and bovine serum albumin (100 μg). 0.3 ml, sodium azide (2 mg / kg) and sodium deoxyribonucleinate (20 mg / kg) are also administered intraperitoneally for three days. One week after the start of the simulation, cyclophosphamide (100 mg / kg) is additionally injected intramuscularly, and complete Freund's adjuvant and bovine deoxyribonucleic acid (2.5 mg / kg each) are added to the root of the tail. From the following day, sodium deoxyribonucleinate (20 mg / kg), cyclophosphamide (100 mg / kg), 0.1 ml of a 10% solution of angio-associated serine proteinase-3 (Wieslab-AB-Lund, Sweden) were administered intraperitoneally daily for one week. , which is a precursor of antineutrophil cytoplasmic antibodies, and 1 ml of 0.05% solution of orthophthalic aldehyde (a derivative of homocysteine, which damages the vascular wall, causes vasothrombosis and endothelial vascular dysfunction). 2 weeks after the start of modeling on the background of intra-abdominal nembutal anesthesia (50 mg / kg) by decapitation of animals removed from the experiment. |
| priorityDate | 2019-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.