http://rdf.ncbi.nlm.nih.gov/pubchem/patent/UA-118627-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-16 |
| filingDate | 2017-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | UA-118627-C2 |
| titleOfInvention | METHOD OF PREPARATION OF (±) -CIS-3- (1H-BENZIMIDAZOL-2-IL) -1,2,2-TRIMETHYL-CYCLOPENTENTERCARBIC ACID OR ЇЇ OPTICALLY ACTIVE ISOMERS |
| abstract | The invention relates to the chemical and pharmaceutical field, namely to the organic synthesis of (±) -cis-3- (1H-benzimidazol-2-yl) -1,2,2-trimethylcyclopentanecarboxylic acid or its optically active isomers, carried out in two chemical stages - at first carry out acylation of o-phenylenediamine anhydride (±) -camphoric acid to obtain the intermediate product (±) -α-2'-aminophenylamide-1,3-dicarboxylic acid, which is then subjected to cyclodehydration to obtain (±) -cis- 3- (1H-benzimidazol-2-yl) -1,2,2-trimethylcyclopentanecarboxylic acid, followed by purification and separation in crystallized form upon cooling, whereby acylation of o-phenylenediamine anhydride (±) -camphoric acid is carried out in a temperature range from 60 ° C to 100 ° C in an organic solvent selected from benzene, toluene, xylene or dioxane, and cyclodehydration (±) -α-2'-aminophenylamide-1,3-dicarboxylic acid is carried out in the temperature range from 101 ° C to 120 ° C in the medium of organic solvents selected from benzene, toluene, xylene, dioxane, dimethylformamide or mixtures thereof, preferably mixtures of toluene and smoke ethylformamide taken in the ratio (3: 0.3-0.5), removing from the reaction medium intramolecular water in the form of azeotropic mixture of water-toluene, in addition, purification of (±) -cis-3- (1H-benzimidazole -2-yl) -1,2,2-trimethylcyclopentanecarboxylic acid is carried out by washing with 20-50% ethyl alcohol, followed by its dissolution in boiling 96% ethyl alcohol in the presence of activated carbon and filtration of the resulting solution. |
| priorityDate | 2017-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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