| abstract |
This application relates to new substituted (aza) pyridopyrazolopyrimidinones and indazolopyrimidinones, methods for their preparation, compounds for use alone or in combination in a method of treatment and / or prevention of diseases, in particular treatment and / or prevention of acute and recurrent bleeding blood clotting, with or without blood flow, where the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum bleeding, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver disease, hereditary angiodystrophy, bleeding from the nose and synovitis and cartilage damage followed by hemarthrosis. |